Pertuzumab is the next-generation molecular targeted drug and cure the HER2-positive breast cancer to inhibit the dimerization of HER2 receptors.Today, pertuzumab was approved by FDA and it can be used to treatment HER2-positive breast can…

At ASCO 2012, it was shown that Gemcitabine might not improve the prognosis of the HER2-negative and lymph node positive breast cancer patients.For the adjuvant chemotherapy to the HER2-negative and lymph node positive breast cancer patien…

Now we can use several adjuvant chemotherapy for the breast cancer treatment after surgery, but it is not clear which is the best. Because each patient have different background and the breast cancer is classified to several subtype, to ha…

BBC said that the awareness of cannabis smoking.The cannabis is illegal drug in Japan, but other countries is not. Although I don't know the thinking of cannabis in UK, maybe several people are thinking that smoking cannabis is one of recr…

Generally, it is difficult to research the cause of the pediatric disease because of the small population.For example, the drug dosage for the pediatric disease isn't strictly decided, and the pharmacy have to calculate depend on children …

BBC announced that"Aspirin could reduce the risk of skill cancer".Skin cancer is usually classified the three, such as basal cell carcinoma, squamous cell carcinoma, or the rarer but more dangerous malignant melanoma.The News shows that th…

The circular tumor cells mean the tumor cell floating in the blood.When the tumor grows, the partial cells are apart from the tumor mass. And then, their cells go into the vessel and start to flow.Usually, it is used cytological diagnosis …

HER2 positive gastric cancer is recently focused well because the Herceptin was approved in Japan.Before chemotherapy, the diagnosis of HER2 status is needed at the gastric cancer tissue. Usually, it is used immunohistochemical analysis an…

Abbott got the approval of FISH kit for detection of ALK fusion gene. This kit is planned to utilize before Crizotinib treatment.Crizotinib is known as XALKORI and desined to inhibit ALK protein (made by Phizer). This drug has been approve…

Aspirin is the most famous drug in the world and is widely used as the anti-inflammatory drugs to pain control. In Japan, it is well-known as the very affordable painkiller too.In this paper, the researchers indicated that this drug could …

Hormone receptor positive breast cancer shows that ER or PgR receptor is over expressing in the cancer cell. Recently, the treatment of breast cancer is thought to classify the breast cancer subclass based on the molecular marker before tr…

Trastuzumab (Herceptin) is the first molecular target drug for HER2 positive breast cancer. At present, this is first-line drug for their patients.Trastuzumab is only approved as an intravenous formulation now, but the hypodermic injection…

DCIS (ductal carcinoma in situ) is thought to be very early stage of breast cancer. With advancing the technology, we have analyzed DCIS and gradually understood.This news said that if DCIS patients be treated by radiation therapy after su…

Pertuzumab is a antibody drug to HER2 receptor and is expected as a new medicine to treat the HER2 positive breast cancer. At present, HER2 positive breast cancer treatment is used Trastuzumab (Herceptin) and Lapatinib (Tykerb).However, it…

The circular tumor cells (CTCs) are the floating cells within the blood.Basically, CTCs peel off from the solid tumor mass and start floating within the blood. CTCs finally attach to the another tissue and then metastasis is realized. Ther…

From the present report, it was shown that a lot of people don't take the cancer screening test. Japanese Government try to to increase the number of person who take screening test. However, this effect is still weak.Surely, cancer screeni…

I think caner vaccine is the next generation cancer theraphy.Vaccine can enhance the immune respose and attack the target. Threfore, camcer vaccine could cure the cancer patients. However, cancer vaccine is difficult to stratify the respon…

Sunitinib is called Sutent and is used to treat renal cell carcinoma and imatinib-resistant GIST(gastrointestinal stromal tumor) in Japan.This drug inhibits the signal pathway beneath the VGDF receptors and the PDGF receptors and shows the…

Angiogenesis is a key factor of progression and metastasis. Bevacizumab is a anti-body drug, which shows the anti-cancer effect to inhibit VEGF signaling. Ombrabulin is a vascular disrupting agent, which is combretastatin A4 derivatives. C…

International Cancer Gennome Consortium (ICGC) and the National Cancer Institute (NCI) opened the Cancer Genome Database.Both of them categorized all genes by cancer type. We can search the relationship by the gene name, Ensembl ID and Gen…

HER2 is one of the famous cancer bio-marker, especially breast cancer. HER2 positive breast cancer patients is well-known to indicate poor prognosis. Herceptin is the drug, which attacks the HER2 positive breast cancer cell and enhances th…

National Center for Biotechnology Information (NCBI) opened the Genetic Testing Resistry (GTR). This site maybe is useful for bio-marker hunting. We can overview the various clinical data at this site. Home - Genetic Testing Registry (GTR)…

The prognosis of breast cancer have improved as a result of long-term clinician's efforts. Recently, 10 years recurrence free survival rate of breast cancer is very high.However, the patients have to take the medication for a long time aft…

PSA screening test is used to diagnose the prostate cancer in US. On the other hand, Japan doesn't recognize the PSA test as the effective test because of a poor evidence. I wrote this topic in the previous diary.Today, U.S. Preventive Ser…

Pancreatic cancer is one of the worst cancer in the world.If this cancer developed, the symptom is very slightly. Generally, this cancer has progressed severely, when we feel the backache, poor appetite and so on.Therefore, we are wanting …

Circulation tumor cells (CTCs) are metastatic bio-marker of breast cancer metastasis.Previously, cancer cells are known to be separated from tumor mass, when the breast cancer progresses. Therefore, CTCs is derived from epithelia and expre…

BRCA1/2 is one of the most famous mutation about cancer. Familial breast cancer is often detected these mutation.BRCA1/2 functions the gene repair enzyme. Therefore if the mutation has occurred, the breast cancer cell would be easy to be c…

Pancreatic cancer is one of the worst cancer in the worlds. This cancer is hard to diagnose in the early stage, so we often have no way to treat the patients when the cancer is found.Today's BBC said that combination therapy of gemcitabine…

This news is Japanese translation and related to this dialy.This news shows all diagnostic markers, so I write below. 早期の非小細胞肺癌（NSCLC）の術後の転帰について、従来から用いられている病期分類よりも正確に転帰不良の患者を同定できるアル…

The gastric cancer could develop the metastasis to membranes of the abdomen as a result of the surgery. Because a few cancer cell would be spreading to abdominal space during surgery. Therefore, the surgeon has to estimate the risk of meta…